World Heart Federation
Return to index

PROGRAMME HIGHLIGHTS FROM THE WORLD CONGRESS OF CARDIOLOGY 2008

With 17,500 participants from over 100 countries attending the World Congress of Cardiology 2008 the Scientific Programme was designed to fulfil the congress theme “From Patients to Populations”. Organised jointly by the World Heart Federation, the Argentine Society of Cardiology and the Argentine Federation of Cardiology, delegates from developed and developing countries had the opportunity to present and learn about the latest scientific advances and treatments for the management of cardiovascular diseases as well as to review the preventative approaches for tackling the rising global burden. 

Unique audience reach

The World Congress of Cardiology is unique in its focus in that it moves beyond the high tech discussions found in North America and Europe and concentrates on the developing countries where 80% of deaths occur and where strategies may be slightly different. By sharing science, building capacity and developing partnerships the congress aims to fight the rising burden of cardiovascular disease globally. With over 250 sessions to choose from some programme highlights are featured below: 

Hypertension treatment in patients aged over 80 years reduces mortality by 21%

Hypertension (high blood pressure) is a global risk factor for cardiovascular disease and stroke. The HYVET trial (Hypertension in the Very Elderly) which included 3,854 patients aged over 80 years, who received a combination of Indapamide and Perindopril showed that mortality rates were reduced by 21%. The results which were presented Dr Guillermo Fabregues, Vice-President of the Argentine Cardiology Foundation provided the first solid evidence on the usefulness of the pharmacological treatment of hypertension among the elderly.

The results of three other relevant clinical trials on hypertension were also discussed and included:

  • The ADVANCE trial that showed a reduction of 18% in the rate of cardiovascular death, whilst the combination of perindopril and indapamide reduced blood pressure down to 134/75 mmHg
  • The ONTARGET trial that compared the effectiveness of the angiotensin converting enzyme inhibitor (ramipril) with the angiotensin receptor blocker (telmisartan) showed that both drugs are similar in terms of their ability to reduce cardiovascular events
  • The ACCOMPLISH trial was the first to compare the combination of an angiotensin converting enzyme inhibitor with a calcium blocker (benazepril /amlodipine, respectively) versus the combination of an angiotensin converting enzyme inhibitor with a diuretic (benazepril/hydrochlorothiazide) finding that the first combination was significantly superior in reducing cardiovascular events.

Polypill reaches clinical testing phase

Polypill sessions were dedicated to the presentation of research results and also featured a debate on the different aspects of Polypill development and use. Led by Dr Valentin Fuster, immediate Past President of the World Heart Federation the Polypill has now reached the clinical testing phase. It is the result of collaboration between the Spanish National Centre for Cardiovascular Research (CNIC), of which Dr Fuster is Scientific President, and the Ferrer laboratory in Spain.

Spanish researchers will start clinical testing in 2008, of a three-in-one pill to prevent heart attacks, which they hope to launch worldwide in 2010 for less than $10 a month; the new pill is a combination of aspirin, statin and ACE inhibitor. It has already been reviewed by the FDA (Food and Drug Administration) and now moves forward to the clinical trial phase to test further parameters related with pharmacodynamics and pharmacokinetics.

This new pill is designed for secondary prevention, helping to prevent heart attack patients suffering a recurrence. It is not intended for primary prevention or daily use by people with no history of heart attack. Dr Fuster said that “Today, within one year of a myocardial infarction, between a third and half of all patients are not taking the three drugs they need and are not correcting their risk factors,” he also added “There are a variety of explanations for this behaviour, but the polypill will be more affordable, more available and a more convenient method of treatment”.

Stress at work increases the progression of arteriosclerosis

Work stress, resulting from great pressure in the work place, may increase the progression of atherosclerosis by 46% in people who have highly reactive personalities to stress. This was demonstrated by a study performed by researchers at the School of Public Health in Berkeley, USA, which found that the association of stress and very demanding work in a personality highly reactive to stress, results in the thickening of the internal walls of the carotid arteries and formation of atherosclerotic plaques which progressively obstruct blood flow. Both factors are markers of the progression of atherosclerosis that underlies cardiovascular disease.

Dr C. Noel Bairey Merz, Director of the Preventive and Rehabilitative Cardiac Center at Cedars-Sinai in the USA said “although it is difficult to estimate how many people are at risk of coronary disease because of work stress, the most recent analysis of the INTERHEART study makes it possible to estimate that from 20–30% of heart attacks can be attributed to psychological stress”. The INTERHEART study, covered 52 countries and a population of 25,000 patients.

Environmental risk factors: tobacco and air pollution

There was a whole series of discussions on air pollution ranging from presentations on particulate matter and how it is increasing worldwide, through automative pollutants and factory emissions and the impact this is having on cardiovascular disease. New scientific evidence on the damage caused by second-hand tobacco smoke was also presented and results showed that those who are habitually exposed to passive smoke run a cardiovascular risk almost as high as those who smoke; people who do not smoke but inhale second-hand smoke suffer a 30% increased risk of cardiovascular disease.

The most alarming fact was that as little as 30 minute of exposure is enough to produce observable changes in the arterial function of non-smokers. The longer the arteries of non-smokers are exposed to second-hand smoke the more they behave like the arteries of smokers. This evidence further supports the worldwide efforts to decrease smoking in public areas, enabling the public to exercise their right to good health.    

Thank you

The World Heart Federation and World Congress of Cardiology organisers would like to extend their gratitude to all the Speakers and Chairs for their hard work and dedication as well as the congress participants for contributing to the success of the 16th congress. 

Access the 8 webcast sessions and the congress abstracts >

top of the page