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Systematic evaluation of PPCM in Nigeria

Professor Kamilu Karaye, an Emerging Leader from the 2014 cohort (TakeMeds project) is currently the principal investigator on the largest systematic evaluation of PPCM in Nigeria, which it is hoped that the information will assist in understanding the disease better and developing locally applicable interventions for the disease.

The project is being conducted in collaboration with the Nigerian Cardiac Society, a member of the World Heart Federation.

About the Project

Title: Peripartum Cardiomyopathy in Nigeria (PEACE) Registry

Brief summary: Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality, and Nigeria probably has the highest burden of the disease in the world. Unfortunately, much about the disease including its aetiology, epidemiology and treatment is not yet well described. This will be a prospective, national, multicenter cohort study, conducted in centres in Nigeria. It is expected that approximately 500 patients with PPCM and 500 apparently healthy pregnant women will be recruited over a 6-month period with follow‐up at 3-monthly intervals for 18 months.

Background: Nigeria probably has the highest burden of Peripartum Cardiomyopathy (PPCM) in the world. The primary objective is to describe the burden, ventricular remodelling and survival of PPCM in Nigeria. In the sub-studies, we aimed to describe the relationship between selenium deficiency, oxidative stress and PPCM, the impact of sodium selenite supplementation on left ventricular reverse remodelling, change in New York Heart Association functional class and survival in PPCM, and the prevalence of selenium deficiency and its relationship with cardiac function in apparently healthy pregnant women.

Further information: